Fans chanted "Melo! Melo!" when the Knicks had the ball in the second half, as if they were calling a play. That was replaced by "We Want Melo! We want Melo!" after he checked out.
He made 20 of his first 26 shots against what had been a good defensive team, but there was no defense for the zone Anthony was in.
"When he's in one of those zones, ain't nothing nobody can do about it," Jefferson added.
Last season's scoring champion had eight points in the first 2½ minutes, went 8 of 10 in the first quarter and had 20 points as the Knicks led 30-21. He skipped his usual break and kept playing deep into the second quarter before finally taking a seat with 4:34 left, shortly after missing an open jumper.
He returned with 2½ minutes left to finish the half in style, throwing in a buzzer beater from just inside halfcourt to cap his 15-of-21 half and make it 67-46, Stoudemire laughing hysterically on the bench in his brown suit jacket and the rest of the players leaping in celebration.
"Just to see everybody smiling once again, that's what I was more excited to see," Anthony said. "Guys on the bench smiling, high-fiving, having fun once again, that's the only thing I care about."
Turned out Anthony was just getting started.
He made his first five shots in the second half and the Bobcats would eventually grow frustrated, picking up two technical fouls on one play after Anthony's 3-pointer late in the third.
He made both free throws, part of his 10-for-10 showing at the line, and said he tried to check himself out earlier but his teammates wouldn't allow it.
Congrats to my brother @carmeloanthony on setting a franchise record tonight! #RocketLauncherFromBirth http://t.co/jArREJpMUXGame notes
— LeBron James (@KingJames) January 25, 2014
Information from The Associated Press was used in this report.