Knox now is more guarded, less outgoing. She is studying creative writing at the University of Washington, but in her first days back in Seattle she has struggled to break some of her prison routines, like washing her laundry each night in a bucket. She tells her sisters some of the tricks she learned in prison: using rubber bands to shave her legs.
It was a world she was unprepared for in the days after the murder as police, the prosecutor and the press zeroed in on Knox and her then boyfriend, Raffaele Sollecito. The young couple was unaware that their every moved was watched and every phone call bugged. In the days after the murder, a famous video of Knox and Sollecito kissing outside the crime scene rocketed around the world.
Looking back, Knox explains, "It never occurred to me that I would ever be considered a suspect. Ever."
All eyes were on the young couple of just seven days. Knox's odd behavior and lack of visible grief would come back to haunt her. Investigators and press drew attention to all of her actions, like allegedly doing a cartwheel at the police station while waiting to be questioned.
"I never did a cartwheel. I did do a split," Knox admits, adding that she was stretching after sitting for hours when a police officer commented on her flexibility.
Her behavior went beyond doing a split. Knox sat in Sollecito's lap. They kissed, made faces at each other and she stuck her tongue out at him. She said she wanted to write a song about this and wrote she would kill for a pizza. The police reprimanded them and asked them to stop.
Kercher's British friends cast doubt on Knox's innocence, testifying that Knox had shown little remorse at the police station, lacked grief and was sitting on Sollecito's lap, playfully making faces while in the waiting area.
But Knox's own words proved most damning.
In the hours and days after the murder, Knox and Sollecito told police the same story of their whereabouts the night of Kercher's murder -- they had spent the night at Sollecito's apartment.
But on her fourth day of questioning by police, during an overnight interrogation, Knox's story changed. She said she was in the house that night, in the kitchen covering her ears as Kercher screamed, and that her boss, Patrick Lumumba had killed Meredith.
Lumumba, a bar owner for whom Knox worked, had sent her a text message the night Kercher was murdered telling her not to come to work. It was a holiday weekend and business was slow.
She texted Lumumba back, "See you later." Knox says police insisted the text was proof she had met up with Lumumba that night.
"When they pushed me about [Lumumba's] message, and told me to think, to remember that I had met him, I can only describe it as breaking down. I didn't know what I remember anymore. I was wracking my brain for an answer to what happened."
Knox insists police yelled at her, threatened her with 30 years in prison, cuffed the back of her head, and told her she had amnesia.
An emotional Knox recalls, "I was demolished in that interrogation."
Sollecito was interrogated in another room. He also cracked and told police Knox may have left his apartment the night of the murder.
Within hours, Knox, Sollecito and Lumumba were arrested and taken to prison. But just two weeks later, Lumumba was released because he had an airtight alibi.
ABC News contacted experts around the country who state it is documented that coerced and false confessions happen frequently, but less frequent is naming an innocent bystander.
Justin Brooks, director of the California Innocence Project, points out the danger of people being interrogated without a lawyer present is that "sometimes we end up getting false statements and false confessions."
"Innocent people do often confess to crimes they haven't done," he adds. According to the Innocence Project website, "in about 25 percent of DNA exoneration cases, innocent defendants made incriminating statements, delivered outright confessions or pled guilty."
Famed defense lawyer Alan Dershowitz agrees people do sometimes falsely confess, but "what I rarely found in my experience is innocent people pointing the finger at another innocent person, saying I didn't do it, but I was there, he did it. That's very rare, for an innocent person."
Patrick Lumumba was not there. He says because of Amanda Knox his two weeks in jail ruined his reputation and his life.
Knox is still angry that her crucial interrogation was not recorded. She says it is the only time she was questioned by police that where no recording exists. The prosecutor, Giulino Mignini, says they didn't tape her interrogation to save money, despite the fact they were bugging her and Sollecito's phone calls and conversations in waiting rooms.