They're all currently top-10 players, and like the rest of the ATP World Tour Querrey has struggled with big fellows. His combined record against Djokovic, Nadal, Murray and Roger Federer is 2-17. He may soon have a chance to spiff up that mark.
Here are the three other Friday matches featuring Americans:
No. 1 Serena Williams versus No. 31 Daniela Hantuchova: A win here gives Williams the all-time record for main-draw victories at the Australian Open. She is currently tied with Margaret Court at 60. They've met nine times, with Williams winning eight. Interestingly, Hantuchova's only win came in Melbourne, in the 2006 third round. The winner gets a Grand Slam champion, either Samantha Stosur or Ana Ivanovic.
Lauren Davis versus No. 30 Eugenie Bouchard: This is a clash between two of the WTA's emerging young players. Davis, 20 and a resident of Boca Raton, Fla., is ranked No. 68 and off to a torrid start for 2014. She won four matches (three qualifying) in Sydney and two matches each in Auckland and Melbourne. Davis is into the third round of a major for the first time. She has never met the 19-year-old Canadian, who is ranked No. 31.
Alison Riske versus No. 9 seed Angelique Kerber: Risk, 23 and a resident of Atlanta, is 2-2 this year and is 0-1 for her career against the hard-hitting German. The victor, along with the winner of the Flavia Pennetta- Mona Barthel match, will reach the Australian Open quarters for the first time.