"And the only thing that is left is the police's word verses mine, and a couple of documents I signed when I had no lawyer present. This is what I'm up against," Knox laments.
As Knox sat in a grey, concrete prison cell, prosecutors declared that the murder was a drug-fueled sex game gone wrong. Knox, they said, was the ringleader.
The prosecution claimed they had a knife, the alleged murder weapon, with Kercher's DNA on the blade and Knox's on the handle.
They said that Kercher's bra clasp, which had been cut from the rest of the bra, had Sollecito's DNA on one prong. But police found no DNA whatsoever of Knox in Kercher's bedroom where she was killed.
While the lawyers battled over a minute scrap of what they claimed was Sollecito's DNA, there was a great deal of DNA at the murder scene that matched a local man, Rudy Guede. Guede's shoe print and hand prints were found in the victim's blood. His DNA was also on her removed clothing and her purse, which was missing credit cards and 300 euros. It was also found inside Kercher's body.
Guede had a history of drug abuse and theft. He robbed a nursery school, law office and home, at times threatening people with a knife.
Police arrested Guede, who had fled to Germany. In a secretly recorded Skype phone call with a friend before his arrest, Guede said he was at Kercher's house the night she was murdered, but that he had been in the bathroom on the toilet when Kercher was killed by an intruder.
Guede also said Knox was not at the house that night, but when asked whether Sollecito -- "the one from TV" news -- might have been there, Guede says, "I think so, but I'm not sure," according to Knox's memoir.
Knox and Sollecito stayed in prison, and the press ran with their headlines calling Knox the "angel faced killer." The case became an international media frenzy, and the eccentric girl from Seattle was in the center of it all.
In 2009, Knox and Sollecito's trial began in a medieval courtroom, the press packed inside, fighting for the perfect shot of the "American Temptress," as one headline read.
In the courtroom, Lumumba's attorney called her "a devil."
"It's one thing to be called certain things in the media, and then it's another things to be sitting in a courtroom, fighting for your life while people are calling you a devil," Knox said.
As Knox sat through her year-long trial, she listened to Mignini present a series of motives, and in the end, during his closing arguments, Mignini said there was no motive at all.
Knox was stunned when the court found her guilty of murder and sentenced her to 26 years in prison. It is a moment Knox will never forget, "I was carried out of the courtroom by the armpits, moaning that it was impossible. I just -- complete and utter disbelief."
As she remembers hearing her mother and sister wail, Knox's voice cracks with emotion.
"For all intents and purposes, I was a murderer, whether I was or not. And I had to live with the idea that would be my life. I would be one of those people who suffered an incredible, mind-boggling injustice," she said.
After her conviction, Knox says she had to rethink her life.
"I felt assassinated as if I were being sealed in a tomb. And the tomb was my life, it wasn't prison."
She says she considered suicide.
In her book, Knox writes that she often wondered what would be the breaking point to drive her to kill herself. Possibly, she thought, if she lost her appeal and her sentence was increased to life in prison, that would be it.
She says there were many ways to kill oneself in prison, and she "imagined doing them all."